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Limin International Group Co. Ltd ,a fast-growing company founded by returned scholars and their partners, is mainly engaged in R&D, production, and sales of bioactive proteins and clinical diagnostic reagents.


Category:Recombinant Proteins

Description:Humanepididymisprotein4,HE4(Fctag) Ovariancancerismalignanttumor ,which is comm only occurred inovarian tissue. Its in cidence is the thirdofthethreemajorgynecologicalmalignanttumors. Foritsearlysymptomisnotobviousa...


Human epididymis protein 4, HE4 (Fc tag)

Ovarian cancer is malignant tumor, which iscommonly occurred in ovarian tissue. Its incidence is the third of the threemajor gynecological malignant tumors. For its early symptom is not obvious andnot easy to find, the 5-year survival rate of patients decreases from 70-90% to20% as the time goes on, so early diagnosis is important for the cure rate ofovarian cancer. HE4 are surface antigen of women ovarian tumor cell. AlthoughCA125 is widely used in the clinical diagnosis of ovarian cancer, studies haveshown that HE4 has more advantages in the early diagnosis of ovarian cancerthan CA125, especially for patients at the start of ovarian cancer. HE4 is thebest tumor markers currently in ovarian cancer diagnosis.

HE4 is found in epididymis epithelium.HE4 is the product of selective cutting of WFDC2 gene and has a highlyconservative WAP (Whey Acidic Proteins) domain structure, which has fourdisulfide bond core region that formed by eight cysteine.

The HE4(Fc tag) providedby our company is a recombinant protein expressed by mammalian cells, with highpurity, good immunogenicity and high biological activity. It is a fusion protein with human Fc fragment. It was verified to be an ideal biologicalraw material for IVD. Antibody to this antigen protein can beused as the core material of ovarian cancer early diagnosis kit, and theprotein itself can also be used as calibration items.

Product details:

Cas#: LM-208
From: liquid
Constituents: Recombinant human HE4(Fc tag) was dissolved in 1 xPBS(pH7.4)
Concentration: 1-2mg/ml
Shipment: ice bag
Source: A DNA sequece encoding the human HE4(NM_006103.3) fused with the Fc regin of human IgG1 was expressed by HEK293 cells.
Molecular weight: Recombinant human HE4(Fc tag) migrates as approximately 44-50 kDa band in SDS-PAGE under reducing conditions.
Purity: >90% (determined by SDS-PAGE)
Storage: 4℃ for frequent usage,-20℃ for long-term storage. Avoid repeated freeze-thaw cycles.
Figure: he4