Details

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FAP

(Fibroblast activation protein alpha Fibroblast activation protein alpha, also known as seprase or 1 70 kda melanoma membrane-bound gelatinase, is a protein that in humans Is encoded by the fap gene(2q23 ). It is a homodimeric integral membrane

gelatinase belongingto the serine protease family. It is selectively expressed in reactive stromalfibroblasts of epithelial cancers, granulation tissue of healing wounds, andmalignant cells of bone and soft tissue sarcomas. This protein is thought to beinvolved in the control of fibroblast growth or epithelial-mesenchymalinteractions during development, tissue repair, and epithelial carcinogenesis.

FAP, also known asseprase, belongs to the clan SC proteases and is a member of the S9B prolyloligopeptidase subfamily. Other members of the S9B subfamily are DPPIV, DPP8 and DPP9. FAP is most closely related to DPPIV and they shareabout 50% of their amino acids.

FAP is catalyticallyactive as a 170kD dimer and has dipeptidase and gelatinase activity. Itsgelatinase activity requires a glycine in P2 position.

The FAP provided by our company is a recombinant proteinexpressed by mammalian cells, with high purity, good immunogenicity and highbiological activity.

Product details：

Cas#:	LM-206
From:	liquid
Constituents:	Recombinant human FAP was dissolved in 1 xPBS(pH7.4)
Concentration:	1-2mg/ml
Shipment:	ice bag
Source:	A DNA sequece encoding the human FAP(NM_004460.3) extracellular domain fused with a affinity tag was expressed by HEK293 cells.
Molecular weight:	Recombinant human FAP migrates as approximately 90 kDa band in SDS-PAGE under reducing conditions.
Purity:	>95% (determined by SDS-PAGE)
Storage:	4℃ for frequent usage,-20℃ for long-term storage. Avoid repeated freeze-thaw cycles.
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