Details

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ErbB1（EGFR）

Asa member of the epidermal growth factor receptor (EGFR) family, EGFR protein istype I transmembrane glycoprotein that binds a subset of EGF family ligandsincluding EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays acrucial role in signaling pathway in the regulation of cell proliferation,survival and differentiation. Binding of a ligand induces EGFR protein homo- orheterodimerization, the subsequent tyrosine autophosphorylation and initiatesvarious down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFRsignaling also has been shown to exert action on carcinogenesis and diseaseprogression, and thus EGFR protein is proposed as a target for cancer therapycurrently.

The EGFRprovided by our company is a recombinant protein expressed by mammaliancells, with high purity, good immunogenicity and high biological activity. It was verified tobind therapeutic antibodie”Erbitux” with high affinity.

Product details：

Cas#:	LM-414
From:	liquid
Constituents:	Recombinant human EGFR was dissolved in 1 xPBS(pH7.4)
Concentration:	1-2mg/ml
Shipment:	ice bag
Source:	A DNA sequece encoding the human EGFR(NM_005228.3) fused with the Fc regin of human IgG1 was expressed by HEK293 cells.
Molecular weight:	Recombinant human EGFR migrates as approximately 95-115 kDa band in SDS-PAGE under reducing conditions.
Purity:	>95% (determined by SDS-PAGE)
Storage:	4℃ for frequent usage,-20℃ for long-term storage. Avoid repeated freeze-thaw cycles.
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