Limin International Group Co. Ltd ，a fast-growing company founded by returned scholars and their partners, is mainly engaged in R&D, production, and sales of bioactive proteins and clinical diagnostic reagents.  . . .
Description：ErbB1（EGFR）Asamemberoftheepidermalgrowthfactorreceptor(EGFR) family,EGFRproteinistypeItransmembraneglycoprotein thatbindsasubsetofEGFfamilyligandsincludingEGF, amphiregulin,TGF-α,betacellulin,etc.EGFR...
Asa member of the epidermal growth factor receptor (EGFR) family, EGFR protein istype I transmembrane glycoprotein that binds a subset of EGF family ligandsincluding EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays acrucial role in signaling pathway in the regulation of cell proliferation,survival and differentiation. Binding of a ligand induces EGFR protein homo- orheterodimerization, the subsequent tyrosine autophosphorylation and initiatesvarious down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFRsignaling also has been shown to exert action on carcinogenesis and diseaseprogression, and thus EGFR protein is proposed as a target for cancer therapycurrently.
The EGFRprovided by our company is a recombinant protein expressed by mammaliancells, with high purity, good immunogenicity and high biological activity. It was verified tobind therapeutic antibodie”Erbitux” with high affinity.
|Constituents:||Recombinant human EGFR was dissolved in 1 xPBS(pH7.4)|
|Source:||A DNA sequece encoding the human EGFR(NM_005228.3) fused with the Fc regin of human IgG1 was expressed by HEK293 cells.|
|Molecular weight:||Recombinant human EGFR migrates as approximately 95-115 kDa band in SDS-PAGE under reducing conditions.|
|Purity:||>95% (determined by SDS-PAGE)|
|Storage:||4℃ for frequent usage,-20℃ for long-term storage. Avoid repeated freeze-thaw cycles.|